Curvature effects in interfacial acidity of amphiphilic vesicles.

Abstract

We analyze the changes in the vicinal acidity (pH) at a spherical amphiphilic membrane. The membrane is assumed to contain solvent accessible, embedded, dissociable, charge-regulated moieties. Basing our approach on the linear Debye-Hückel approximation, as well as on the nonlinear Poisson-Boltzmann theory, together with the general Frumkin-Fowler-Guggenheim adsorption isotherm model of the charge-regulation process, we analyze and review the dependence of the local pH on the position, as well as bulk electrolyte concentration, bulk pH, and curvature of the amphiphilic single membrane vesicle. With appropriately chosen adsorption parameters of the charge-regulation model, we find a good agreement with the available experimental data.