DeepSlice: rapid fully automatic registration of mouse brain imaging to a volumetric atlas.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37735467.
- Also identified by DOI 10.1038/s41467-023-41645-4 and PMC identifier 10514056.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Registration of data to a common frame of reference is an essential step in the analysis and integration of diverse neuroscientific data. To this end, volumetric brain atlases enable histological datasets to be spatially registered and analyzed, yet accurate registration remains expertise-dependent and slow. In order to address this limitation, we have trained a neural network, DeepSlice, to register mouse brain histological images to the Allen Brain Common Coordinate Framework, retaining registration accuracy while improving speed by >1000 fold.
Medical subject headings
- Ascomycota