Breaking barriers for glioblastoma with a path to enhanced drug delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37737212.
- Also identified by DOI 10.1038/s41467-023-41694-9 and PMC identifier 10517119.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Progress in treatment for glioblastoma is hindered by the blood-brain barrier (BBB). In genetic mouse models recapitulating brain invasion and abnormal angiogenesis of human glioblastoma, Cai and colleagues demonstrate that optical modulation of the BBB with nanoparticles boosts intratumoural chemotherapy concentration, prolonging survival. We discuss prospects for clinical translation of exemplary innovative techniques.
Medical subject headings
- Glioblastoma