Recyclable and Robust Optical Nanoprobes with Engineered Enzymes for Sustainable Serodiagnostics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37738281.
- Also identified by DOI 10.1002/adma.202306615.
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Abstract
Recyclable fluorescence assays that can be stored at room temperature would greatly benefit biomedical diagnostics by bringing sustainability and cost-efficiency, especially for point-of-care serodiagnostics in developing regions. Here, a general strategy is proposed to generate recyclable fluorescent probes by using engineered enzymes with enhanced thermo-/chemo-stability, which maintains an outstanding serodiagnostic performance (accuracy >95%) after 10 times of recycling as well as after storage at elevated temperatures (37 °C for 10 days). With these three outstanding properties, recyclable fluorescent probes can be designed to detect various biomarkers of clinical importance by using different enzymes.
Medical subject headings
- Fluorescent Dyes
- Enzymes
- Diagnosis