Linking donor-specific antibody generation with natural killer cells in antibody-mediated kidney graft rejection.
Where this comes from
- Record sourced from PubMed, PMID 37739612.
- Also identified by DOI 10.1016/j.kint.2023.07.014.
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Abstract
Natural killer (NK) cell infiltration of kidney allografts is a distinguishing feature of antibody-mediated rejection. Bailly et al. identify a distinct population of cytotoxic CD160<sup>+</sup> interleukin-21 receptor<sup>+</sup> CD56<sup>dim</sup>CD16<sup>bright</sup> NK cells that are uniquely found in the peripheral blood of donor-specific antibody-positive kidney transplant recipients and are present in kidney allografts with active antibody-mediated rejection. This population is implicated in a T follicular helper/interleukin-21/NK cell axis that links donor-specific antibody generation with graft-infiltrating NK cells in antibody-mediated rejection.
Medical subject headings
- Graft Rejection
- Antibodies