Suppressing succinate accumulation during ischemia protects the kidney from IRI.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37739613.
- Also identified by DOI 10.1016/j.kint.2023.07.011.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Previous studies have indicated that succinate accumulation during kidney ischemia, and its oxidation during reperfusion, results in the production of excessive reactive oxygen species, mitochondrial dysfunction, and kidney injury. In this issue, Oh et al. have reported that pyruvate dehydrogenase kinase 4 (PDK4) inhibition in proximal tubules ameliorates kidney ischemia/reperfusion injury via suppressed succinate accumulation. This study suggests that PDK4 inhibition is a promising new treatment strategy for ischemic acute kidney injury.
Medical subject headings
- Succinic Acid
- Acute Kidney Injury