A Genetic Risk Variant for Multiple Sclerosis Severity is Associated with Brain Atrophy.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 37753809.
- Also identified by DOI 10.1002/ana.26807 and PMC identifier 11303986.
- Licence recorded as CC BY-NC-ND.
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Abstract
The minor allele of the genetic variant rs10191329 in the DYSF-ZNF638 locus is associated with unfavorable long-term clinical outcomes in multiple sclerosis patients. We investigated if rs10191329 is associated with brain atrophy measured by magnetic resonance imaging in a discovery cohort of 748 and a replication cohort of 360 people with relapsing multiple sclerosis. We observed an association with 28% more brain atrophy per rs10191329*A allele. Our results encourage stratification for rs10191329 in clinical trials. Unraveling the underlying mechanisms may enhance our understanding of pathophysiology and identify treatment targets. ANN NEUROL 2023;94:1080-1085.
Medical subject headings
- Multiple Sclerosis
- Central Nervous System Diseases
- Neurodegenerative Diseases