Evaluating a low anion gap: A practical approach.

Haber, Lawrence A; Dhaliwal, Gurpreet; Lo, Lowell; Rizzuto, Gabrielle · Cleve Clin J Med · 2023

review · Level V

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Abstract

In teaching and in practice, little attention is given to a low anion gap. This oversight can result in a missed opportunity to diagnose acute or chronic disorders requiring treatment. In this article, we review the constituents of the anion gap, build a differential diagnosis for a low anion gap using case examples, and provide a stepwise approach to diagnostic testing to evaluate this abnormal finding.

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