Losing the forest for the trees: The complexities of fibrinolysis will never be explained with one variable alone.

Coleman, Julia R; Moore, Ernest E; Kelher, Marguerite R; Jones, Kenneth; Cohen, Mitchell J; Banerjee, Anirban; Silliman, Christopher C · J Trauma Acute Care Surg · 2024

expert_opinion · Level V

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Abstract

Fibrinolytic shutdown (versus hypofibrinolysis) = plasmin burst followed by diminished fibrinolysis. After thrombin and plasmin burst, fibrinolysis is inhibited, mediated by increased TAFI. #TAFI #TIC #surgscience @JuliaColemanMD @CUDeptSurg @DenverHealthMed @OhioStateSurg @mitchelljayc

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