Treatment of Multiple Bone Metastases of Castration-Resistant Prostate Cancer With 225 Ac-PSMA-617.

Yang, Hongyu; Zhang, Yu; Su, Dan; Zhang, Yu; Chen, Yue · Clin Nucl Med · 2023

case_report · Level V

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Abstract

177 Lu-prostate-specific membrane antigen (PSMA) for metastatic castration-resistant prostate cancer has emerged as a very promising therapy. However, some of the PSMA-expressing positive metastatic castration-resistant prostate cancer patients never respond or develop resistance to 177 Lu-PSMA. We present a case of castration-resistant prostate cancer with multiple bone metastases. Remission of clinical symptoms and imaging lesions can be observed after 4 cycles of 225 Ac-PSMA-617 therapy. Moreover, the man did not have any observable adverse effects.

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