Molecular mechanocytometry using tension-activated cell tagging.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37798479.
- Also identified by DOI 10.1038/s41592-023-02030-7 and PMC identifier 11325290.
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Abstract
Flow cytometry is used routinely to measure single-cell gene expression by staining cells with fluorescent antibodies and nucleic acids. Here, we present tension-activated cell tagging (TaCT) to label cells fluorescently based on the magnitude of molecular force transmitted through cell adhesion receptors. As a proof-of-concept, we analyzed fibroblasts and mouse platelets after TaCT using conventional flow cytometry.
Medical subject headings
- Flow Cytometry