Crosslinking strategies in modulating methylcellulose hydrogel properties.

Abstract

Methylcellulose (MC) hydrogels are ideal materials for the design of thermo-responsive platforms capable of exploiting the environment temperature as a driving force to activate their smart transition. However, MC hydrogels usually show reduced stability in an aqueous environment and low mechanical properties, limiting their applications' breadth. A possible approach intended to overcome these limitations is chemical crosslinking, which represents a simple yet effective strategy to modify the MC hydrogels' properties (<i>e.g.</i>, physicochemical, mechanical, and biological). In this regard, understanding the selected crosslinking method's role in modulating the MC hydrogels' properties is a key factor in their design. This review offers a perspective on the main MC chemical crosslinking approaches reported in the literature. Three main categories can be distinguished: (i) small molecule crosslinkers, (ii) crosslinking by high-energy radiation, and (iii) crosslinking <i>via</i> MC chemical modification. The advantages and limitations of each approach are elucidated, and special consideration is paid to the thermo-responsive properties after crosslinking towards the development of MC hydrogels with enhanced physical stability and mechanical performance, preserving the thermo-responsive behavior.