Probing conformational dynamics to understand kinase inhibition.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 37850630.
- Also identified by DOI 10.7554/eLife.92753 and PMC identifier 10584368.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Why do some inhibitors select the on-state in ERK2, a kinase that is involved in many signaling pathways in cells, whereas others bind to more than one conformation?
Medical subject headings
- Signal Transduction