Randall-Type Monoclonal Immunoglobulin Deposition Disease in Bone Scintigraphy.
case_report · Level V
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- Record sourced from PubMed, PMID 37883135.
- Also identified by DOI 10.1097/RLU.0000000000004927.
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Abstract
Bone scintigraphy is recognized as a noninvasive alternative to endomyocardial biopsy for the diagnostic of wild-type (wATTR) and hereditary ATTR amyloidosis (hATTR). Light chain amyloidosis (AL), Randall-type monoclonal immunoglobulin deposition disease , sarcoidosis, hemochromatosis, Fabry disease, and mucopolysaccharidoses are differential diagnosis of ATTR amyloidosis. Bone scintigraphy allows visualization of extracardiac involvements of AL amyloidosis: pleural, retroperitoneal, liver, spleen, and soft tissue. We report the case of a patient who underwent bone scintigraphy for suspected ATTR amyloidosis. Bone scan showed cardiac (Perugini score 2), hepatic, and renal hyperfixation. A cardiac biopsy demonstrated a Randall-type deposit, without amyloid deposit.
Medical subject headings
- Amyloidosis
- Heart Diseases
- Multiple Myeloma
- Cardiomyopathies