The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia.

Whiteside, Garth T; Kyle, Donald J; Kapil, Ram P; Cipriano, Alessandra; He, Ellie; Zhou, Mingyan; Shet, Manjunath S; Hummel, Michele et al. · J Clin Invest · 2024

basic_science · Level V

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Abstract

The potent and partial agonist sunobinop activates the nociceptin/orphanin-FQ peptide receptor and promotes non-REM sleep in rodents and patients with insomnia.

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