Increased Metabolic Activity of the Thymus and Lymph Nodes in Pediatric Oncology Patients After Coronavirus Disease 2019 Vaccination.
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- Record sourced from PubMed, PMID 37884331.
- Also identified by DOI 10.2967/jnumed.123.266271 and PMC identifier 10755519.
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Abstract
We hypothesized that <sup>18</sup>F-FDG PET/MRI would reveal thymus activation in children after coronavirus disease 2019 (COVID-19) vaccination. <b>Methods:</b> We retrospectively analyzed the <sup>18</sup>F-FDG PET/MRI scans of 6 children with extrathoracic cancer before and after COVID-19 vaccination. We compared pre- and postvaccination SUV<sub>max</sub>, mean apparent diffusion coefficient, and size of the thymus and axillary lymph nodes using a paired <i>t</i> test. <b>Results:</b> All 6 patients showed increased <sup>18</sup>F-FDG uptake in the axillary lymph nodes after vaccination (<i>P</i> = 0.03). In addition, these patients demonstrated increased <sup>18</sup>F-FDG uptake in the thymus. When compared with baseline, the postvaccination scans of these patients demonstrated an increased mean thymic SUV (<i>P</i> = 0.02), increased thymic size (<i>P</i> = 0.13), and decreased thymic mean apparent diffusion coefficient (<i>P</i> = 0.08). <b>Conclusion:</b> <sup>18</sup>F-FDG PET/MRI can reveal thymus activation in addition to local lymph node reactions in children after COVID-19 vaccination.
Medical subject headings
- Fluorodeoxyglucose F18
- COVID-19