Tandem-biocatalysis reactors constructed by topological evolution of CaCO<sub>3</sub> particles into hollow metal hydroxide spheres.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37884545.
- Also identified by DOI 10.1038/s41467-023-42649-w and PMC identifier 10603116.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Despite remarkable advances in the design and synthesis of hollow inorganic spheres (HISs), the harsh synthetic conditions have precluded the applications of HISs to biochemical and biological fields. Herein we report a biocompatible strategy for synthesizing metal hydroxide HISs (MH-HISs) by simply mixing CaCO<sub>3</sub> particles with metal ions in water. The ion-exchange reaction between Ca<sup>2+</sup> and metal ions leads to the structural and chemical evolution from solid CaCO<sub>3</sub> particles to hollow MH-HISs via core-shell and yolk-shell structures, while enabling the encapsulation of enzymes to the shells without loss of catalytic activities. The biocompatible protocol makes multienzymatic cascade reactions achievable, with great recyclability due to mechanical durability of MH-HISs.