Molecular Engineering of Luminogens for High-Integrity Imaging of Hydrogen Polysulfides via Activatable Aggregation-Induced Dual-Color Fluorescence.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37889140.
- Also identified by DOI 10.1021/acsnano.3c08767.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Understanding biological events associated with H<sub>2</sub>S<sub><i>n</i></sub> rather than mediated by H<sub>2</sub>S is of great significance but remains to be solved due to a lack of high-integrity imaging tools. In this study, we report a chemoselective probe for H<sub>2</sub>S<sub><i>n</i></sub> over H<sub>2</sub>S through the molecular engineering of luminogens. Based on our search for H<sub>2</sub>S<sub><i>n</i></sub>-activatable probes with high selectivity, we fabricate water-soluble and biocompatible nanoprobes. Such a designed nanoprobe shows rare aggregation-induced dual-color fluorescence responses to H<sub>2</sub>S<sub><i>n</i></sub>, lighting up bright emissions at 588 and 750 nm, respectively. By use of this activatable dual-color fluorescence, high-integrity identification of intracellular H<sub>2</sub>S<sub><i>n</i></sub> was successfully realized. Thus, our approach to H<sub>2</sub>S<sub><i>n</i></sub>-activated multicolor fluorescent probes could provide valuable insight into interrogating H<sub>2</sub>S<sub><i>n</i></sub>-mediated biological events.
Medical subject headings
- Hydrogen
- Hydrogen Sulfide