Early Efficacy End Points in Neoadjuvant Rectal Cancer Trials: Surrogacy Revisited.

Fokas, Emmanouil; Smith, J Joshua; Garcia-Aguilar, Julio; Glynne-Jones, Robert; Buyse, Marc; Rödel, Claus · J Clin Oncol · 2024

review · Level V

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Abstract

Trial-level surrogacy is critical before early response endpoints are used to approve new therapies.

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