Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37907454.
- Also identified by DOI 10.1038/s41467-023-41880-9 and PMC identifier 10618265.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Follicular helper T cells (T<sub>FH</sub>) mediate B cell selection and clonal expansion in germinal centers (GCs), and follicular regulatory T cells (T<sub>FR</sub>) prevent the emergence of self-reactive B cells and help to extinguish the reaction. Here we show that GC reactions continually recruit T cells from both the naïve conventional and naive thymic regulatory T cell (Treg) repertoires. In the early GC, newly recruited T cells develop into T<sub>FH</sub>, whereas cells entering during the contraction phase develop into T<sub>FR</sub> cells that contribute to GC dissolution. The T<sub>FR</sub> fate decision is associated with decreased antigen availability and is modulated by slow antigen delivery or mRNA vaccination. Thus, invasion of ongoing GCs by newly developing T<sub>FH</sub> and T<sub>FR</sub> helps remodel the GC based on antigen availability.
Medical subject headings
- T-Lymphocytes, Regulatory
- T-Lymphocytes, Helper-Inducer