Genome editing-induced t(4;11) chromosomal translocations model B cell precursor acute lymphoblastic leukemias with KMT2A-AFF1 fusion.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37917159.
- Also identified by DOI 10.1172/JCI171030 and PMC identifier 10760968.
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Abstract
A t(4;11) leukemia model established from CRISPR-engineered chromosomal translocations between the KMT2A and AFF1 genes recapitulate proteomic, epigenomic, and transcriptomic features of primary patient leukemias.
Medical subject headings
- Translocation, Genetic
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma