Hiding from allogeneic NK cells and macrophages by a synthetic receptor.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 37922874.
- Also identified by DOI 10.1016/j.stem.2023.10.005.
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Abstract
Immune attack by natural killer (NK) cells is a major hurdle for allogeneic off-the-shelf cell therapy, especially when HLA molecules are removed. Gravina et al.<sup>1</sup> utilized a membrane-anchored single-chain antibody (scFv) as a synthetic receptor, named "synthetic immune checkpoint engager," to prevent attack from NK cells and macrophages.
Medical subject headings
- Receptors, Artificial
- Hematopoietic Stem Cell Transplantation