Multilineage circuits of regenerative cell states.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 37922876.
- Also identified by DOI 10.1016/j.stem.2023.10.006.
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Abstract
Regenerating the lungs' architecture after injury requires rebuilding its fibroelastic extracellular matrix scaffold. Konkimalla et al. establish that regenerative cell states (RCSs) of both epithelial and mesenchymal origin are functionally linked and indispensable for this process. Experimental ablation of RCSs causes organ degeneration, whereas their induction causes organ fibrosis.
Medical subject headings
- Extracellular Matrix