Clinical Phenotypes and Molecular Characteristics of Respiratory Syncytial Virus in Adults: A Monocentric Prospective Study Between 2019 and 2022.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 37926099.
- Also identified by DOI 10.1093/infdis/jiad479.
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Abstract
Respiratory syncytial virus (RSV) infection is a major cause of pneumonia in adults. Little is known on the viral genetic diversity and the associated clinical phenotypes in this population. This single-center prospective cohort study included RSV-infected patients hospitalized between January 2019 and December 2022. Of 100 patients, including 41 with severe infection, 72 were infected with RSV-B. RSV genome sequencing showed no clustering according to severity. Patients infected with RSV-B with risk factors for severe pneumonia had significantly higher fusion protein diversity scores. No amino acid substitutions conferring resistance to nirsevimab were detected.
Medical subject headings
- Respiratory Syncytial Virus, Human
- Respiratory Syncytial Virus Infections
- Pneumonia