On-Demand Aligned DNA Hydrogel Via Light Scanning.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37947399.
- Also identified by DOI 10.1021/acsnano.3c07493.
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Abstract
DNA is an anisotropic, water-attracting, and biocompatible material, an ideal building block for hydrogel. The alignment of the anisotropic DNA chains is essential to maximize hydrogel properties, which has been little explored. Here, we present a method to fabricate the anisotropic DNA hydrogel that allows precise control for the polymerization process of photoreactive cationic monomers. Scanning ultraviolet light enables the uniaxial alignment of DNA chains through the polymerization-induced diffusive mass flow using a concentration gradient. While studying anisotropic mechanical properties and orientation recovery according to the DNA chain alignment direction, we demonstrate the potential of directionally controlled DNA hydrogels as smart materials.
Medical subject headings
- Hydrogels
- DNA