An Activated Structure Transformable Ratiometric Photoacoustic Nanoprobe for Real-Time Dynamic Monitoring of H<sub>2</sub>S <i>In Vivo</i>.
basic_science · Level V
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- Record sourced from PubMed, PMID 37955992.
- Also identified by DOI 10.1021/acs.nanolett.3c03980.
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Abstract
H<sub>2</sub>S has emerged as a promising biomarker for many diseases such as colon cancer and metformin-induced hepatotoxicity. Real-time monitoring of H<sub>2</sub>S levels <i>in vivo</i> is significant for early accurate diagnosis of these diseases. Herein, a new accurate and reliable nanoprobe (Au NRs@Ag) was designed for real-time dynamic ratiometric photoacoustic (PA) imaging of H<sub>2</sub>S <i>in vivo</i> based on the endogenous H<sub>2</sub>S-triggered local surface plasmon resonance (LSPR) red-shift. The Au NRs@Ag nanoprobe can be readily converted into Au NRs@Ag<sub>2</sub>S via the endogenous H<sub>2</sub>S-activated <i>in situ</i> sulfurative reaction, subsequently leading to a significant red-shift of the LSPR wavelength from 808 to 980 nm and enabling accurate ratiometric PA (PA<sub>980</sub>/PA<sub>808</sub>) imaging of H<sub>2</sub>S. Moreover, dynamic ratiometric PA imaging of metformin-induced hepatotoxicity was also successfully achieved by the designed PA imaging strategy. These findings provide the possibility of designing a new ratiometric PA imaging strategy for dynamic <i>in situ</i> monitoring of H<sub>2</sub>S-related diseases.
Medical subject headings
- Metformin
- Chemical and Drug Induced Liver Injury