Systems genetics approaches for understanding complex traits with relevance for human disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 37962168.
- Also identified by DOI 10.7554/eLife.91004 and PMC identifier 10645424.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Quantitative traits are often complex because of the contribution of many loci, with further complexity added by environmental factors. In medical research, systems genetics is a powerful approach for the study of complex traits, as it integrates intermediate phenotypes, such as RNA, protein, and metabolite levels, to understand molecular and physiological phenotypes linking discrete DNA sequence variation to complex clinical and physiological traits. The primary purpose of this review is to describe some of the resources and tools of systems genetics in humans and rodent models, so that researchers in many areas of biology and medicine can make use of the data.
Medical subject headings
- Multifactorial Inheritance
- Systems Biology