Biopatterning of 3D Cellular Model by Contactless Magnetic Manipulation for Cardiotoxicity Screening.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37974427.
- Also identified by DOI 10.1089/ten.TEA.2023.0197.
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Abstract
Impact statement Contactless manipulation and cell patterning techniques provide rapid and cost-effective three-dimensional (3D) cell culture model formation for tissue engineering applications. The present study introduces a new methodology that comprised alginate-based bioink to pattern cells via contactless magnetic manipulation to fabricate 3D cardiac structures. The developed cardiac model was evaluated in terms of Doxorubicin-induced cardiotoxicity and biopatterned 3D cardiac structures were found more resistant to drug exposure compared to two-dimensional control.
Medical subject headings
- Cardiotoxicity
- Doxorubicin