Laminin-521: a novel target for pathogenic autoantibodies in anti-glomerular basement membrane disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 37981425.
- Also identified by DOI 10.1016/j.kint.2023.09.017.
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Abstract
Anti-glomerular basement membrane (anti-GBM) disease is typically characterized by autoimmunity against the α3 chain of type IV collagen. Rarely, circulating autoantibodies are not detected. These atypical cases follow a more indolent clinical course, and underlying mechanisms, including alternative target antigens, require investigation. In this issue of Kidney International, Kuang et al. describe a case of anti-GBM disease with autoantibodies against the GBM component laminin-521 and demonstrate that laminin-521 is pathogenic in a rat model of anti-GBM glomerulonephritis.
Medical subject headings
- Anti-Glomerular Basement Membrane Disease
- Glomerulonephritis