Enhanced Antibacterial and Wound Healing Using a Metal-Organic Cluster Inspired by Artificial Photosynthesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37993108.
- Also identified by DOI 10.1002/adhm.202302087.
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Abstract
Bacterial infection poses a constant threat to human health. It is crucial to develop cost-effective and multifunctional solutions to combat bacteria. In this study, inspiration has been taken from artificial photosynthesis and a hydrogel containing a photocatalytic metal-organic cluster (MOC) has been creatively formulated for wound healing and antibacterial purposes. Complete photocatalytic cycles have been achieved by combining the oxidative Ti-center and the reductive Cu-center, in which reactive oxygen species (<sup>1</sup> O<sub>2</sub> and ·OH) have been generated. The MOC has the capability to eliminate Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) at a concentration of 40 µg mL<sup>-1</sup> . In addition, the hydrogel formulation (H-MOC) has been applied to wounds infected with S. aureus, resulting in improved healing efficiency. This work presents an innovative approach to utilizing photocatalytic biomaterials as non-antibiotic medications.
Medical subject headings
- Escherichia coli
- Staphylococcal Infections