GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders.

Leggio, Lorenzo; Hendershot, Christian S; Farokhnia, Mehdi; Fink-Jensen, Anders; Klausen, Mette Kruse; Schacht, Joseph P; Simmons, W Kyle · Nat Med · 2023

review · Level V

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Abstract

Preclinical and initial human studies suggest that glucagon-like peptide-1 receptor agonists may be promising treatments for alcohol use disorder, but existing approved treatments should be used until safety and efficacy is demonstrated in clinical trials.

Medical subject headings