Genomic Characterization of Methicillin-Susceptible Staphylococcus aureus Carriage in Patients on Home Parenteral Nutrition and Their Caregivers.

Gompelman, Michelle; van Weerdenburg, Ingrid J M; Wezendonk, Guus T J; Coolen, Jordy P M; Akkermans, Reinier P; Rovers, Chantal P; Wertheim, Heiman F L; Wanten, Geert J A · Clin Infect Dis · 2024

prospective_cohort · Level II

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Abstract

In this prospective study, patients on home parenteral nutrition were twice as likely to be colonized with Staphylococcus aureus if their caregivers were carriers. Among S. aureus-positive patients and their caregivers, molecular analysis showed 68% genetically related strains. Despite decolonization, genetically related strains reappeared in 70% of patients.

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