Resting-state global brain activity affects early β-amyloid accumulation in default mode network.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38012153.
- Also identified by DOI 10.1038/s41467-023-43627-y and PMC identifier 10682457.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
It remains unclear why β-amyloid (Aβ) plaque, a hallmark pathology of Alzheimer's disease (AD), first accumulates cortically in the default mode network (DMN), years before AD diagnosis. Resting-state low-frequency ( < 0.1 Hz) global brain activity recently was linked to AD, presumably due to its role in glymphatic clearance. Here we show that the preferential Aβ accumulation in the DMN at the early stage of Aβ pathology was associated with the preferential reduction of global brain activity in the same regions. This can be partly explained by its failure to reach these regions as propagating waves. Together, these findings highlight the important role of resting-state global brain activity in early preferential Aβ deposition in the DMN.
Medical subject headings
- Amyloid beta-Peptides
- Alzheimer Disease