Prolonged Mpox Disease in People With Advanced HIV: Characterization of Mpox Skin Lesions.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 38019806.
- Also identified by DOI 10.1093/infdis/jiad532 and PMC identifier 10965209.
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Abstract
We report 3 complicated and prolonged cases of mpox in people with advanced human immunodeficiency virus (HIV) not on antiretroviral therapy (ART) at mpox diagnosis. Multiple medical countermeasures were used, including prolonged tecovirimat treatment and immune optimization with ART initiation. Immunofluorescence of skin biopsies demonstrated a dense immune infiltrate of predominantly myeloid and CD8+ T cells, with a strong type I interferon local response. RNAscope detected abundant replication of monkeypox virus (MPXV) in epithelial cells and dendritic cells. These data suggest that prolonged mpox in people with advanced HIV may be due to ongoing MPXV replication, warranting aggressive medical countermeasures and immune optimization.
Medical subject headings
- Mpox, Monkeypox
- Skin Diseases
- HIV Infections