BNIP3 as a new tool to promote healthy brain aging.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38030595.
- Also identified by DOI 10.1111/acel.14042 and PMC identifier 10861191.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The article "Neuronal induction of BNIP3-mediated mitophagy slows systemic aging in Drosophila" reveals BCL2-interacting protein 3 as a therapeutic target to counteract brain aging and prolong overall organismal health with age. In this spotlight, we consider the roles of BNIP3, a mitochondrial outer membrane protein, in the adult nervous system, including its induction of mitophagy and prevention of dysfunctional mitochondria in the aged brain. Implications for other tissue types to reduce the burden of aging are further considered.
Medical subject headings
- Mitochondrial Proteins
- Mitochondria