Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38036527.
- Also identified by DOI 10.1038/s41467-023-43748-4 and PMC identifier 10689762.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Alkene dicarbofunctionalization is an efficient strategy and operation-economic fashion for introducing complexity in molecules. A nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes for the simultaneous construction of one C(sp<sup>3</sup>)-C(sp<sup>3</sup>) bond and one C(sp<sup>3</sup>)-C(sp<sup>2</sup>) bond has been developed. The mild catalytic method provided valuable indanethylamine derivatives with wide substrate scope and good functional group compatibility. An enantioselective dicarbofunctionalization was also achieved with pyridine-oxazoline as a ligand. The efficiency of metallaphotoredox dicarbofunctionalization was demonstrated for the concise synthesis of pharmaceutically active compounds.