Selective C(sp<sup>3</sup>)-H arylation/alkylation of alkanes enabled by paired electrocatalysis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38042911.
- Also identified by DOI 10.1038/s41467-023-43791-1 and PMC identifier 10693613.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We report a combination of electrocatalysis and photoredox catalysis to perform selective C(sp3)-H arylation/alkylation of alkanes, in which a binary catalytic system based on earth-abundant iron and nickel is applied. Reaction selectivity between two-component C(sp3)-H arylation and three-component C(sp3)-H alkylation is tuned by modulating the applied current and light source. Importantly, an ultra-low anodic potential (~0.23 V vs. Ag/AgCl) is applied in this protocol, thus enabling compatibility with a variety of functional groups (>70 examples). The robustness of the method is further demonstrated on a preparative scale and applied to late-stage diversification of natural products and pharmaceutical derivatives.