DNA methylation rates scale with maximum lifespan across mammals.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38049585.
- Also identified by DOI 10.1038/s43587-023-00535-6 and PMC identifier 10798888.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
DNA methylation rates have previously been found to broadly correlate with maximum lifespan in mammals, yet no precise relationship has been observed. We developed a statistically robust framework to compare methylation rates at conserved age-related sites across mammals. We found that methylation rates negatively scale with maximum lifespan in both blood and skin. The emergence of explicit scaling suggests that methylation rates are, or are linked to, an evolutionary constraint on maximum lifespan acting across diverse mammalian lineages.
Medical subject headings
- Longevity
- DNA Methylation