Fructose sweetens the adipocyte-T cell alliance against tumors.
Where this comes from
- Record sourced from PubMed, PMID 38056424.
- Also identified by DOI 10.1016/j.cmet.2023.11.004.
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Abstract
Dietary fructose is implicated in tumorigenesis, but whether dietary fructose regulates antitumor immunity remains elusive. In this issue of Cell Metabolism, Zhang et al. show that dietary fructose promotes adipocyte-derived leptin production, which attenuates terminal exhaustion programming and boosts the effector function of CD8<sup>+</sup> T cells for improved tumor control.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Neoplasms