mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 38056426.
- Also identified by DOI 10.1016/j.cmet.2023.11.006.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Nutrient availability is conveyed to the mechanistic target of rapamycin (mTOR), which couples metabolic processes with cell growth and proliferation. How mTOR itself is modulated by amino acid levels remains poorly understood. Ge and colleagues now demonstrate that broad sensing of uncharged tRNAs by GCN2/FBXO22 inactivates mTOR complex 1 (mTORC1) via mTOR ubiquitination.
Medical subject headings
- Signal Transduction
- TOR Serine-Threonine Kinases