Redox and detox: Malate shuttle metabolism keeps exhausted T cells fit.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38056428.
- Also identified by DOI 10.1016/j.cmet.2023.11.005.
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Abstract
The malate shuttle is known to maintain the balance of NAD<sup>+</sup>/NADH between the cytosol and mitochondria. However, in T<sub>ex</sub> cells, it primarily detoxifies ammonia (via GOT1-mediated production of 2-KG in an atypical reaction) and provides longevity to chronic-infection-induced T<sub>ex</sub> cells against ammonia-induced cell death.
Medical subject headings
- Malates
- Ammonia