Characterization of Humoral Responses to Nipah Virus Infection in the Syrian Hamster Model of Disease.
basic_science · Level V
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- Record sourced from PubMed, PMID 38064677.
- Also identified by DOI 10.1093/infdis/jiad557 and PMC identifier 11875002.
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Abstract
Nipah virus (NiV) is a highly pathogenic paramyxovirus. The Syrian hamster model recapitulates key features of human NiV disease and is a critical tool for evaluating antivirals and vaccines. Here we describe longitudinal humoral immune responses in NiV-infected Syrian hamsters. Samples were obtained 1-28 days after infection and analyzed by ELISA, neutralization, and Fc-mediated effector function assays. NiV infection elicited robust antibody responses against the nucleoprotein and attachment glycoprotein. Levels of neutralizing antibodies were modest and only detectable in surviving animals. Fc-mediated effector functions were mostly observed in nucleoprotein-targeting antibodies. Antibody levels and activities positively correlated with challenge dose.
Medical subject headings
- Nipah Virus
- Henipavirus Infections
- Mesocricetus
- Antibodies, Viral
- Disease Models, Animal
- Antibodies, Neutralizing
- Immunity, Humoral