Toward a CRISPR understanding of gene function in human brain development.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38065064.
- Also identified by DOI 10.1016/j.stem.2023.11.005.
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Abstract
Genome-wide association studies pinpoint genetic risk factors for neurodevelopmental disorders (NDDs), but the next challenge is to understand the mechanisms through which these genes affect brain development. Two recent CRISPR screens in human brain organoids<sup>1</sup><sup>,</sup><sup>2</sup> interrogate the function of risk genes for autism spectrum disorder and other NDDs.
Medical subject headings
- Autism Spectrum Disorder
- Neurodevelopmental Disorders