A monomeric StayGold fluorescent protein.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38081970.
- Also identified by DOI 10.1038/s41587-023-02018-w and PMC identifier 11392804.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
StayGold is an exceptionally bright and stable fluorescent protein that is highly resistant to photobleaching. Despite favorable fluorescence properties, use of StayGold as a fluorescent tag is limited because it forms a natural dimer. Here we report the 1.6 Å structure of StayGold and generate a derivative, mStayGold, that retains the brightness and photostability of the original protein while being fully monomeric.
Medical subject headings
- Luminescent Proteins