In Search of Lost Biomarker for Immunotherapy in Small Cell Lung Cancer.

Rolfo, Christian; Russo, Alessandro · Clin Cancer Res · 2024

editorial · Level V

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Abstract

Chemo-immunotherapy is the current standard of care for extensive-stage small cell lung cancer, but predictive biomarkers are lacking. In a recent article, the authors report the predictive role of programmed death ligand-1 expression and tissue tumor mutational burden on durvalumab ± tremelimumab + platinum-etoposide efficacy. See related article by Paz-Ares et al., p. 824.

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