Inflammatory bowel disease patients undergoing total hip arthroplasty have higher odds of implant-related complications.

Abstract

This study evaluates whether IBD patients are at increased risk of implant-related complications after THA. A retrospective study from 01 January 2010 to 31 October 31 2020 using an administrative claims database was performed. IBD patients undergoing THA (<i>n</i> = 11,025), without corticosteroid treatment, were propensity score matched to controls in a 1:5 ratio (<i>n</i> = 55,121) based on age, sex, and the Charlson Comorbidity Index (CCI). Outcomes evaluated included periprosthetic fracture, aseptic loosening, prosthetic joint infection, and THA revision within 2 years of index procedure. Chi-square analyses were used to compare the matched cohorts. The association of IBD and implant-related complications was evaluated using logistical regression to calculate odds ratios (ORs), 95% confidence intervals (95% CIs), and <i>p</i>-values. A <i>p-</i>value < 0.001 was used as the significance threshold. Patients with IBD had a greater incidence and odds of total implant complications (7.03% vs. 3.98%; OR 1.76; <i>p</i> < 0.001) compared with matched controls. IBD patients had significantly higher incidence and odds of developing periprosthetic fracture (0.50% vs. 0.20%; OR 2.46; <i>p</i> < 0.001), THA revisions (2.21% vs. 1.17%; OR 1.91; <i>p</i> < 0.001), aseptic loosening (1.45% vs. 0.84%; OR 1.75; <i>p</i> < 0.001), and prosthetic joint infection (2.87% vs. 1.77%; OR 1.64; <i>p</i> < 0.001). Patients with IBD who underwent primary THA had a significantly higher risk of implant-related complications compared to matched controls. Providers should use this study to appropriately assess post-complication risk factors for their patients with IBD.