Accessing gold p-acid reactivity under electrochemical anode oxidation (EAO) through oxidation relay.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38092735.
- Also identified by DOI 10.1038/s41467-023-44025-0 and PMC identifier 10719393.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The gold π-acid activation under electrochemical conditions is achieved. While EAO allows easy access to gold(III) intermediates over alternative chemical oxidation under mild conditions, the reported examples so far are limited to coupling reactions due to the rapid Au<sup>III</sup> reductive elimination. Using aryl hydrazine-HOTf salt as precursors, the π-activation reaction mode was realized through oxidation relay. Both alkene and alkyne di-functionalization were achieved with excellent functional group compatibility and regioselectivity, which extended the versatility and utility of electrochemical gold redox chemistry for future applications.