Strengthening bonds via RyR2 inhibition helps immune suppression.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38099491.
- Also identified by DOI 10.1172/JCI172986 and PMC identifier 10721143.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Foxp3-expressing Tregs employ multiple suppressive mechanisms to curtail conventional T cell (Tconv) responses and establish tissue homeostasis. How Foxp3 coordinates Treg contact-dependent suppressive function is not fully resolved. In this issue of the JCI, Wang and colleagues revealed that Foxp3-mediated inhibition of ryanodine receptor 2 (RyR2) led to strong Treg-DC interactions and enhanced immunosuppression. RyR2 depletion in Tconvs phenocopied this effect and equipped Tconvs with Treg-like suppressive function in multiple inflammatory or autoimmune contexts. This study provides molecular and therapeutic insights underlying how cell-cell contact limits immune reactivity.
Medical subject headings
- T-Lymphocytes, Regulatory
- Ryanodine Receptor Calcium Release Channel