Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38102123.
- Also identified by DOI 10.1038/s41467-023-44139-5 and PMC identifier 10724252.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We present CFdb, a harmonized resource of interaction proteomics data from 411 co-fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis of this resource charts protein abundance, phosphorylation, and interactions throughout the tree of life, including a reference map of the human interactome. We show how large-scale CF-MS data can enhance analyses of individual CF-MS datasets, and exemplify this strategy by mapping the honey bee interactome.
Medical subject headings
- Protein Interaction Mapping
- Proteomics