Customizing cellular signal processing by synthetic multi-level regulatory circuits.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38110405.
- Also identified by DOI 10.1038/s41467-023-44256-1 and PMC identifier 10728147.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
As synthetic biology permeates society, the signal processing circuits in engineered living systems must be customized to meet practical demands. Towards this mission, novel regulatory mechanisms and genetic circuits with unprecedented complexity have been implemented over the past decade. These regulatory mechanisms, such as transcription and translation control, could be integrated into hybrid circuits termed "multi-level circuits". The multi-level circuit design will tremendously benefit the current genetic circuit design paradigm, from modifying basic circuit dynamics to facilitating real-world applications, unleashing our capabilities to customize cellular signal processing and address global challenges through synthetic biology.
Medical subject headings
- Gene Regulatory Networks
- Synthetic Biology